Olini Black Cumin Oil | Cold Pressed, Unrefined, Untreated | Rich in Omega-6, Omega-3, Linoleic Acid | 1 Litre Glass Bottle

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Bes F, Schulz H, Navelet Y, Salzarulo P. The distribution of slow-wave sleep across the night: a comparison for infants, children, and adults. Sleep. 1991;14(1):5–12. Wong KY, Dunn FA, Graham DM, Berson DM. Synaptic influences on rat ganglion-cell photoreceptors. J Physiol. 2007;582(Pt 1):279–96. Liu X, Somel M, Tang L, Yan Z, Jiang X, Guo S, et al. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 2012;22(4):611–22. The homeostatic regulation of sleep is developed by P24 in rats, as shown in a maximum of SWA at light onset and a reduction thereafter [ 21]. Also, prolonged waking elicits an increase in SWA in rats by this age, while younger rats show a compensatory increase in sleep duration instead of increased SWA [ 22]. In mice, SWA increases during recovery sleep only after P24, while a decline in SWA across baseline sleep and an increase during waking is already apparent at P19 [ 23]. The maintenance of synapses is an energy-demanding process (for review, see [ 16]). Thus, neural networks in early life with high-synapse, low-myelin content might have higher energy demands than those of adults, with low-synapse, high-myelin connectivity. Measuring oxygen consumption, which follows a similar developmental time course as synapse density across childhood [ 65], can assess brain energy use. A comparable pattern is observed for glucose utilization [ 66] (Fig. 1).

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